Molecular weight and molecular geometry are the two most commonly used first principle properties to characterize biomolecules. Molecular geometry can be described by the hydrodynamic radius (nm), which is the size of a particle or molecule in a fluid, taking into account its shape, mass, and interactions with the surrounding fluid molecules. The hydrodynamic radius is defined as the radius of a hypothetical sphere that diffuses at the same rate as the particle or molecule in question, under the same conditions (Einstein, 1905). 

This technote is authored by Emil G. P. V. Stender, Senior ApplicationScientist at Fidabio. The experiments were performed by Dr. IainManfield and Emil G. P. V. Stender at the Astbury Centre for StructuralMolecular Biology at Leeds University and followed by additionalexperiments at the Fidabio offices. 

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