Viscosity
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Benefit from automated viscosity measurement.
An accurate viscosity readout increases the levels of transparency and control in e.g. formulations, polysacharide research, cryo-em sample preparation, small molecule development, biopharmaceuticals processing, industrial-scale fermentation or in other cases when viscosoty as such is important to you.
Secondly, FIDA’s automatic viscosity readout compensates for changes in viscosity during each measurement, ensuring consistent data quality. This feature is critical because, in many other technologies, the impact of sample viscosity is often overlooked, potentially leading to inaccurate or misleading results.
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FIDA automatically determines the viscosity of any solution, for every sample measured.
Accuracy:
FIDA’s viscosity meter is capable of measuring viscosities from less than 0.89 cP up to +20 cP with an ability to measure changes as low as 0.2 cP.
Automation:
Compared to other platforms, the correction for viscosity change is automatically built into every FIDA measurement (incl. binding studies, stability studies, and quantifications). In other words, FIDA users do not need to correct anything manually, and the data is correct even if there are unexpected viscosity changes.
Temperature adjustment:
To save time and increase transparency, temperature-induced viscosity changes are managed thanks to its built-in temperature control in both the autosampler and the measurement chamber.
Formulation optimisation:
FIDA measures viscosity of solutions, helping to optimize buffer, detergent, and excipient choices in biopharmaceutical formulations. By understanding how these factors impact viscosity, companies can ensure product stability and manage issues such as syringeability and manufacturability, which are crucial in drug delivery systems, particularly for biologics like monoclonal antibodies. FIDA can track viscosity in varying solution conditions (any buffer, detergent, condensation, ionic strength or pH), which helps to you quantify molecular contributions to solution viscosity.
Cryo-Em sample preparation:
FIDA’s viscosity measurement, combined with simultaneous polydispersity measurement improve Cryo-Em productivity though informed sample optimisation.
Polysaccharide research:
In polysaccharide research, FIDA’s accurate viscosity measurement is key for understanding polymer conformation, size and interactions. FIDA’s ability to measure viscosity in real time enables more detailed insights into the behavior of polysaccharides in different solution conditions, aiding in optimizing their use in industrial and biomedical applications.
Protein fermentation and production:
During protein fermentation, monitoring viscosity helps ensure process efficiency and product quality. FIDA’s automated viscosity monitoring assists in detecting issues related to protein aggregation or changes in concentration, which are critical for optimizing fermentation yields and downstream processing.
How is viscosity measured?
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In every FIDA measurement, the viscosity is calculated based on the time lapse from sample introduction in the capillary till it reaches the detector (the peak point).
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