FIDA Technology

Accelerating Academic Researchers

FIDA’s value as an academic tool lies in its ability to deliver over 10 key biophysicalparameters with a single technology and in a highly flexible experimental environment.

Multiparametric readouts for more productive research

The multiple readouts allow researchers to gather a wealth of information with one assay—ranging from binding affinities and hydrodynamic radii to concentration and stoichiometry—without the need for multiple instruments, cumbersome assay developments or complex workflows. The iterative FIDA approach significantly reduces the time from hypothesis to validation or rejection. A truly adaptable solution for a wide range of research questions in biophysics.

FIDA technology is grounded in the principles of biophysics, delivering absolute measurements that go beyond mere approximations.

This means that instead of relying on relative comparisons, FIDA directly quantifies critical parameters, giving researchers exact, reproducible data. FIDA ensures that your results are consistent and reliable across different experiments and conditions.

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In-Solution Kinetics and Absolute Size

FIDA measures binding kinetics directly in solution, providing a more accurate representation of how molecules behave in their natural state, avoiding the cumbersome workflow of traditional surface-based techniques. The result is precise, easily interpretable, “artefact-free” data on binding affinities and kinetic rates that reflect actual biological conditions. Furthermore, by measuring the absolute size of molecules in solution, FIDA enables monitoring a range of integrity parameters, incl. conformational changes, oligomeric state and protein aggregation—three critical factors influencing drug efficacy and stability.

High Sensitivity Across Concentration Ranges

FIDA excels at measuring interactions across a wide concentration range (pM to mM), fromsmall molecules to large biomolecules. This flexibility is crucial for drug discovery teamswho need to test molecules at varying concentrations without losing sensitivity. Whetherscreening for early hits, optimizing lead compounds, or predicting drug developability, FIDAdelivers the precision needed to confidently assess binding affinity, even in low-concentrationsamples.

Label-Free, Native State Analysis

Traditional methods often require the use of labels or modifications that can interfere with the natural properties of the drug target. With a wide array of detectors available, Fida can operate label-free, preserving the integrity of proteins and other biomolecules. This allows for more reliable data when investigating protein-ligand interactions, which is especially important in the development of biologics where maintaining the natural structure is key

Absolute Data for High-Impact Publications

FIDA delivers absolute, high-quality binding constants, kinetics and interaction data , ensuring reproducibility and accuracy—perfect for peer-reviewed journals and grant applications.

Ease of Use for All Skill Levels

FIDA’s intuitive interface and quick setup mean that even students can master the technology, reducing the training burden on senior researchers and faculty. Furthermore, its clog-free design ensures minimal downtime, meaning your department's research schedule stays on track without costly interruptions.

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Autoantigen TRIM21 (Ro52) assembles pro-1 inflammatory immune complexes following lytic cell death