Structural PDB Correlator
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Seamless structural validation by automatically comparing experimental measurements with PDB or Alphafold codes.
This unique feature enhances accuracy, streamlines workflows, and supports quality control at every stage—from early-stage model validation and protein engineering to manufacturing and academic research—ensuring reliable results, reduced costs, and accelerated discovery.
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How do you benefit?
Optimise of early stages – theoretical models:
FIDA’s Rh measurement can be used to validate or refine theoretical models obtained from PDB structures. Rh derived from a PDB structure can be compared with experimental Rh from FIDA. Significant differences can indicate discrepancies in the predicted vs. actual conformation or folding state, helping refine or validate structural models.
Increase production efficiency & consistency:
Accurate structural models are key in effective therapeutic development. FIDA’s Structural Correlator validation ensures protein therapeutics maintain their intended conformation in solution, reducing efficacy loss or immunogenicity risks. This early detection of structural issues helps save time and costs associated with reformulation or clinical trial setbacks.
Protein Engineering - Shorten the workflows:
For protein engineering, FIDA validates PDB structures in solution, ensuring engineered proteins fold correctly and behave as expected under physiological conditions. This reduces trial-and-error iterations, accelerating the design of proteins for industrial or research applications.
Structural Biology - Facilitated Research and Discovery:
In academic research, FIDA efficiently confirms whether predicted protein conformations match their real-world behavior. This validation accelerates structural biology studies and enhances the pace of discovery, leading to faster, more reliable publication outcomes.
Manufacturing - Ensuring Product Consistency and Quality Control:
In biomanufacturing, FIDA validates PDB/Alphafold models to ensure that proteins produced have correct folding and stability. This early validation prevents structural deviations, improving product consistency and reducing costly production delays.
How does PDB structural correlator work?
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Since FIDA measures the hydrodynamic radius, and has an embedded PDB correlator, every sample tested is automatically checked agains its expected PDB code. This feature can be used as a main measurement goal, or as a side-control metric.
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