Supramolecular Behavior Application Note

The present application note is based on work done in collaboration with Nikokaj Riis Christensen, PhD, et al. at the University of Copenhagen. A potential therapeutic molecule (arbitrarily named mX) was characterized for its properties in aqueous buffer as well as in human plasma. Due to its chemical structure, mX can self-assemble into higher order oligomeric structures, thus transitioning between monomer, oligomer and micelle structures. It was shown that FIDA provided reliable data for determining the transitions between various structures and good quality data for very low concentrations of mX, which was not possible on any other technology. In addition, FIDA experiments elucidated plasma behavior of mX and showed it’s binding to HSA. 

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