Characterization of Molecular Glues – an automated in-solution platform

We demonstrate how the Fida 1 can be employed as an effective tool for characterizing novel molecular glue candidates. The Fida 1 provides fast and accurate determination of ternary complex formation as well as determination of complex sizes, affinity constants, and co-operativity using the dedicated Fidabio software. Here, the study for target protein GSPT1, ligase CRBN-DDB1, and Molecular Glue X (MGX) and lenalidomide is presented.

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