Flow Induced Dispersion Analysis to measure gRNA-Nuclease Interactions for CRISPR-CAS Development

FIDA is a microfluidic technology which utilizes the phenomenon 1 of Taylor’s dispersion to obtain absolute in solution hydrodynamic radius (Rh) of biomolecules. Here we demonstrate how Fida 1 can be employed as an effective tool for characterization of guide RNA (gRNA)-Cas nuclease interactions and as an automated gRNA screening method.

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