Rapid sizing and characterization of bispecific antibodies

We present how the Fida 1 characterises the formation of ternary complex between bispecific antibodies and target antigens. Using µL of sample, we carried out full titrations and measured the affinity of the antigens, the size of the binary and ternary complex, as well as the cooperativity. The cooperativity is a parameter of utmost importance as values much smaller than 1 would disqualify any bispecific antibody for use as a therapeutic. Sixty individual bispecific antibody samples were analysed in a fully automated way within 12 hours, using 40 nL of sample per sizing.

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